Not the first time Twins have come up here (for a list of 429 posts, try this: https://answers.yahoo.com/search/search_result?fr=uh3_answers_vert_gs&type=2button&p=Fender%20twin%20reverb%20amp
The Twin simply has more power than most will ever need, and will meantime punish you with a ridiculously heavy lift every time you want to move it (last time out, one of the guys compared it to being bolted to the floor). By comparison, the 'Deluxe, or the 'Super will generally sound better at a level that won't endanger your ears, damage the paint on the walls, or get you kicked out of the bar for rattling the ice in customer's drinks, all of which the Twin will do, if really "cranked".
I've used and abused Fender tube amps since around 1962, including Bandmaster, Bassman, Super R, Showman, Twin R, Pro R, and Deluxe R. I'll strongly recommend the "50 watt" guys, with just two main power tubes, rather than the "100 watt" guys with four. Best of that run: using two Super's on stage. One I wish I still had: The Deluxe. One that's still here: vintage Pro-Reverb, and sweet.
But. If going after it again, I'd more likely get something from the next gen, like the Hot Rod or Blues DeVille series, stuff like that. And the Mustang line is pretty impressive in its range of sound.
Then there's this guy: http://www.musiciansfriend.com/amplifiers-effects/blackstar-venue-series-ht-club-40-40w-tube-guitar-combo-amp
Happy Holidays, eddie