If I were looking to buy a new amp, I'd go punch through one of these, at least. The make and type is pretty attractive. http://www.musiciansfriend.com/amplifiers-effects/blackstar-venue-series-ht-club-40-40w-tube-guitar-combo-amp
Nasty's pretty right about (sorry Pam Tillis) all the good ones are gone, but I hear Bugera's are a little unreliable, too. Last "new" stuff I played through were Fender's "Hot Rod" and "Blues Deluxe" amps, pretty tasty. My last good amp still here? Vintage Fender Pro with EL84 Yellow Jacket tube kits.
One of your decisions is gonna be going old-school all-tube, vs. a good "modeling" amp. If I were young again, I would definitely have a modeling amp, even if I didn't gig with it - beats the hell out of dragging around a pile of pedals (but not necessarily a programmable multi-effects processor).
So Danny will now STFU - except to note that there is no way in hell you need a 4x12 cab.
EDIT: Well, almost. You're getting a lot of good views from some experienced guys, more than I would have expected. And seeing some differences, so I hope you do also go "kick the tires" at a good music shop, as only your ear matters. My shot at the 4x12 cab was just because they're about as much fun to move as a refrigerator. 2x12 is classic, and having multiple cabs is so versatile - just have to understand "impedance" for a healthy amp.